MAAP’s 2018 masterplan provides a spatial development framework for the hospital to realise aspirations and pillars set out in the Prince Charles Hospital Campus Framework for Renewal. It aims to not only identify locations for the efficient clinical expansion of the existing hospital, but to also resolve existing access and way-finding constraints arising from the site's complex topography, and identify the best potential long term development opportunities for the campus as a whole over coming decades.

The zonal diagram for the campus as a whole established overlapping zones where there is potential to integrate public and private health, research, education and commercial & mixed use opportunities around a new central green heart. The zonal diagram supports an transport network and pattern of urban blocks that unlocks currently underdeveloped parts of the campus and better integrates the hospital into the surrounding urban grain.